Oletethrin is a bacteriostatic combination drug that has a wide range of effects on microorganisms.

The drug can be used to treat a variety of diseases, if they are caused by microorganisms sensitive to the combination of active substances ...

On the market offered in the form of tablets and solution for injection. Among the advantages of this antibiotic, it is worth noting the slow development of resistance to it in bacteria, due to the complex composition.

Clinico-pharmacological group

Combined broad spectrum antibacterial agent, bacteriostatic.

Pharmacy sales terms

It is released on prescription.


How much does Oletetrin in pharmacies? The average price is 160 rubles.

Release form and composition

Dosage form - coated tablets: round, biconvex, pink; 2 layers are visible in the cross-section (25 pieces each in plastic cans or 10 each in blisters, in a cardboard bundle of 1 can, 1 or 2 packs).

Active substances in 1 tablet:

  • Tablets 125 mg: oleandomycin phosphate - 47.5 mg g and tetracycline - 77.5 mg;
  • Tablets 250 mg: oleandomycin phosphate - 95 mg and tetracycline - 155 mg.

Additional components: potato starch, medical talcum, calcium stearate.

Shell composition: vaseline oil, titanium dioxide pigment, vanillin, tween-80, methylcellulose, acid red dye 2С.

Pharmacological effect

The drug violates the synthesis of bacteria and microorganisms. Active substances prevent the formation of peptides and bonds between them.

High sensitivity is manifested by strains of streptococci, staphylococci, Brucella spp., Neisseria gonorrhoeae, Corynebacterium diphtheriae, Ricketsia spp., And Spirochaetaeceae. Bacillus anthracis, Legionella spp., Haemophilus influenzae, Bordetella pertussis, Klebsiella spp. and Enterobacter spp., Clostridium spp. It is quite effective against chlamydia and ureaplasmas, mycoplasmas - can be prescribed for the treatment of STIs. It also helps with barley.

The key advantage of bacteriostatic is that it is combined. Resistance develops less frequently than with tetracycline monotherapy.

Indications for use

The instructions for use indicate the list of pathologies for which this antibiotic is effective:

Diseases of the ENT area:

  • tonsillitis;
  • pharyngitis;
  • angina;
  • otitis media

Respiratory system diseases:

  • sinusitis;
  • bronchitis;
  • pneumonia focal and croupous;
  • abscesses in the lungs;
  • bronchiectasis.

Skin diseases:

  • erysipelas;
  • purulent skin infections

Diseases of the kidneys and the reproductive system:

  • prostatitis;
  • endometritis;
  • cystitis;
  • pyelonephritis;
  • gonorrhea.

It is also effective in purulent meningitis, brucellosis, osteomyelitis, tularemia, and other diseases caused by a bacterial infection sensitive to oleandomycin and tetracycline.


The use of Oletretrin is contraindicated:

  1. Leukopenia;
  2. With mycosis;
  3. During the period of breastfeeding;
  4. Children under 8 years old - in the form of tablets, up to 12 years - in the form of capsules;
  5. With renal / hepatic failure;
  6. Pregnant women;
  7. In case of hypersensitivity to any active or auxiliary component of the drug, as well as to other antibiotics of the tetracycline group and / or macrolides.

The drug is used with caution in patients with impaired liver function.

Use during pregnancy and lactation

During pregnancy, Olethtrin reception is excluded. Tetracycline can have a negative effect on the fetus. You should also not plan a pregnancy if the drug has already been prescribed and taken.

During lactation, bacteriostatic intake is highly undesirable. Otherwise, it is necessary to stop feeding.

Dosage and method of use

In the instructions for use indicated that the pills should be taken orally, drinking water, after a meal.

Average doses used:

  • Adults: 1 tablet of 250 mg 4 times a day, if necessary, increase the daily dose, but not more than 2000 mg;
  • Children over 8 years: 20-30 mg / kg body weight in 4 doses.

V / m, the daily dose for adults - 0.2-0.3 g; the multiplicity of the introduction - 2-3 times. For children older than 8 years, the daily dose is 10-20 mg / kg. In / in jet, for adults - 0.2-0.3 g in distilled or double-distilled water; injection rate - 2 ml / min. In / in drip - 0.1% solution in a 0.9% solution of sodium chloride or in 5% dextrose solution at a speed of 60 drops / min.

The duration of treatment is 5-10 days, depending on the severity of the disease.

Side effects

The following side effects have been reported during clinical trials and practice:

  • nausea;
  • decreased appetite;
  • vomiting;
  • constipation;
  • abdominal pain;
  • diarrhea;
  • glossitis;
  • exophagitis;
  • dysphagia;
  • various allergic reactions (in the form of redness on the skin, itching, rash, eosinolii).

Among the side effects of long-term treatment, dyspeptic disorders, thrombocytopenia, intestinal dysbacteriosis, candidiasis, hypercreatininemia, increased activity of the enzymes of the hepatic system, azotemia, hypercreatininemia, photosensitization, hyperbilirubinemia, hemolytic anemia, development of vitamin deficiency, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid syndrome, ratios, opiosensitization, hyperbilirubinemia, hemolytic anemia, development of vitamin deficiency, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disorder, thyroid disease, thyroid disorder, thyroid disorder, thyroid syndrome, rash therapy.


In case of overdose of the drug may be aggravated severity of the above side effects. Treatment is prescribed symptomatic.

Special instructions

The simultaneous use of Olethetrin with bactericidal preparations and retinol is not recommended.

Olethethrin reduces the effectiveness of oral contraceptives and increases the risk of uterine bleeding in women who take hormonal contraceptives.

After taking the drug for at least two hours, it is not recommended to drink milk and consume dairy products, as they reduce the absorption of oleandomycin and tetracycline. For the same reason, the 2-hour interval is recommended to be observed and, if necessary, simultaneous administration of colestipol, cholestyramine or preparations containing calcium, magnesium, aluminum, iron.

Olethetrin may affect the effectiveness of antithrombotic drugs, so it is necessary to control their concentration in the blood and, if necessary, adjust the dose.

Oletretrin is contraindicated during pregnancy, since tetracycline can lead to fatty infiltration of the liver in the fetus and slow the growth of skeletal bones. Therefore, before starting the medication, women of childbearing age are advised to eliminate pregnancy in order to prevent the use of Oleletrin in the early stages. For the same reason, the entire period of treatment and for some time after the end of the course of therapy should use reliable barrier methods of contraception.

Drug interactions

Oletethrin is less absorbed when taken simultaneously with antacids, iron preparations, dairy products, because of the content of calcium, aluminum, magnesium and iron in them. If you need a parallel course with these tools, the interval between doses should be at least two hours.

Also Oleetrin is not prescribed in conjunction with antibacterial antibacterial agents. A parallel course with vitamin A increases the risk of elevated intracranial pressure. Caution is advised to take Oletretrin with anticoagulants, as it affects their effectiveness.


Structural analogues of the active substance Oleetrin medication does not have. Analogs for pharmacological group (macrolides and azalides):

  • Azitrox;
  • Azithromycin;
  • AzitRus;
  • Binoculars;
  • Wilprafen;
  • Vilprafen Solyutab;
  • Dinaback;
  • Zinerit;
  • Nitrolide;
  • Nitrolide forte;
  • Clarithromycin;
  • Klacid;
  • Macropene;
  • Oleandomycin phosphate;
  • Pilobact;
  • Rovamycin;
  • Roxithromycin;
  • Romiklar;
  • Rulid;
  • Safotsid;
  • Sumamed;
  • Sumamed forte;
  • Sumamecin;
  • Sumamoks;
  • Sumatrolide Soluteb;
  • Fromilid;
  • Fromilid Uno;
  • Hemomycin;
  • Ecomed;
  • Erythromycin;
  • Erifluid;
  • Hermicid;
  • Esparoxy.

Before using analogues consult your doctor.

Storage conditions and shelf life

Store the drug in a dry place at a temperature not higher than 25 ° C. Shelf life - 2 years. Do not use after expiration date.

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