Antibiotic Vancomycin

Such a representative of the glycopeptide group of antibiotics like vancomycin is used mainly for the treatment of quite serious diseases of bacterial etiology.

The drug is active against streptococci, corynebacteria, staphylococcus, clostridia and other gram-positive microorganisms.

On this page you will find all the information about Vancomycin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Vancomycin. Want to leave your opinion? Please write in the comments.

Clinico-pharmacological group

An antibiotic of the glycopeptide group.

Pharmacy sales terms

It is released on prescription.

Prices

How much is vancomycin? The average price in pharmacies is 200 rubles.

Release form and composition

Vancomycin is produced in the form of a dry powder (lyophilisate) for the preparation of an infusion solution, in dosages of 500 mg and 1000 mg, in vials. Each bottle with the instruction is placed in a cardboard box. Another dosage form of Vancomycin is tablets.

The main active ingredient is vancomycin (in the form of hydrochloride).

Pharmacological effect

Vancomycin is an antibiotic of the group of glycopeptides, which has a bactericidal effect by blocking the synthesis of cell walls and pathogenic microorganisms that are sensitive to it.

The drug violates the synthesis of RNA, changes the permeability of bacteria. The drug is active against streptococci, corynebacteria, staphylococcus, clostridia and other gram-positive microorganisms. Gram-negative sticks, viruses, fungi, protozoa and mycobacteria are resistant to Vancomycin.

Vancomycin is not used in tablets, for the reason that after oral administration the absorption of the active substance is poor, although, according to the testimony of the doctor, the solution can be used orally for some diseases. As a rule, infectious diseases of a systemic nature are treated by administering the solution intravenously.

Indications for use

It is considered appropriate to use this antibiotic for the treatment of such diseases:

  • endocarditis with acute and subacute course;
  • pneumonia caused by bacteria susceptible to this antibiotic;
  • caused by Clostridium difficile enterocolitis (which is also called antibiotic-associated);
  • bacterial meningitis, encephalitis and encephalomyelitis;
  • septicemia, osteomyelitis;
  • local bacterial infections of subcutaneous adipose tissue and skin.

It can also be used for other infections in case of failure of the prescribed antibiotics or their intolerance.

Contraindications

According to the instructions, Vancomycin is contraindicated in:

  1. Neuritis of the auditory nerve;
  2. High patient sensitivity to vancomycin;
  3. Pronounced disorders in the kidneys;
  4. The first trimester of pregnancy and lactation.

The drug is carefully used:

  1. With moderate and mild disorders of the kidneys;
  2. In the second and third trimesters of pregnancy;
  3. Hearing impairment (including history).

Use during pregnancy and lactation

Vancomycin can be administered to pregnant patients only for health reasons. If there is a safe alternative, it is recommended to use another antimicrobial agent.

If vancomycin is administered to a breastfeeding woman, breastfeeding is temporarily stopped.

Instructions for use

In the instructions for use indicated that Vancomycin administered in / drip.

  • Adults - 500 mg every 6 hours or 1 g every 12 hours. To avoid collaptoid reactions, the duration of the infusion should be at least 60 minutes. Children - 40 mg / kg / day, each dose should be administered for at least 60 minutes. In patients with impaired renal excretory function, the dose is reduced based on the CC values.

Depending on the etiology of the disease, vancomycin can be taken orally. For adults, the daily dose is 0.5-2 g in 3-4 doses, for children - 40 mg / kg in 3-4 doses.

The maximum daily dose for adults with a / in the introduction of 3-4 g.

Side effects

When taking the drug, the following side effects are possible: hearing loss, tinnitus, vertigo. Vancomycin can affect the processes of hemostasis and blood formation, causing reversible leukopenia, neutropenia, thrombocytopenia, eosinophilia, and in extremely rare cases - agranulocytosis.

  • The drug may cause gastrointestinal disorders (diarrhea, nausea, vomiting, pseudomembranous colitis), and with long-term use - nephrotoxicity, which can turn into renal failure.

With the rapid introduction of the drug, anaphylactoid reactions are possible: dizziness, bronchospasm, pressure reduction, fever, rapid heartbeat, skin rash, redness of the upper half of the body, muscle spasms in the back and neck. Sometimes there are local reactions: pain and tissue necrosis at the site of infusion, thrombophlebitis.

Special instructions

  1. During the period of treatment with vancomycin, it is advisable to regularly monitor kidney function (indicators of urea nitrogen, creatinine and urinalysis).
  2. In the treatment of newborns and elderly patients, it is recommended to monitor the concentration of the active ingredient of the drug in the blood serum.
  3. The use of Vancomycin in the second and third trimesters of pregnancy can be carried out only on prescription and in cases where the potential benefit to the mother outweighs the possible risk to the fetus.
  4. Combination with local anesthetics in adult patients can lead to a violation of intracardiac conduction, and in children - to hyperemia of the skin of the face and erythematous rash.
  5. The combination of the drug with general anesthetics increases the likelihood of adverse reactions, especially lowering blood pressure and the development of neuromuscular blockade. Therefore, it is recommended to carry out an infusion at least an hour before the introduction of general anesthetics.

Drug interactions

The simultaneous use of local anesthetics and vancomycin can lead to the development of histamine-like tides, erythema and anaphylactic shock.

When used together with cisplatin, aminoglycosides, furosemide, amphotericin B, polymyxins and cyclosporine, there is an increase in nephro- and ototoxic effects.

Reviews

Strong antibiotic, taken with caution and under medical supervision.

Many reviews also contain information on the development of serious side effects, such as a reduction in pressure, difficulty breathing, redness of the skin, a feeling of palpitations, and pain in the ears.

Analogs

Analogues are the drugs: Vankaditsin, Vanko, Vankogen, Vankolon, Vankomek, Vankum, Lykovanum, Tankofeto, Editsin.

Before using analogues consult your doctor.

Storage conditions and shelf life

Vancomycin is stored in a dry place, protected from sunlight, at room temperature (below 25 ° C). Shelf life is 2 years. Do not use an antibiotic after the expiration date indicated on the package.

Watch the video: Vancomycin. Bacterial Targets, Mechanism of Action, Adverse Effects (November 2019).

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