Tablets Betalok ZOK (25, 50, 100 mg): instructions for use

Betalok ZOK belongs to the group of selective beta1-adrenoblockers that do not possess intrinsic sympathomimetic activity.

This drug is characterized by its ability to have a mild membrane stabilizing effect on the human body. However, it is completely devoid of the activity of a partial agonist.

On this page you will find all the information about Betalok ZOK: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Betalok ZOK. Want to leave your opinion? Please write in the comments.

Clinico-pharmacological group

Beta1- blocker.

Pharmacy sales terms

It is released on prescription.

Prices

How much is Betalok ZOK? The average price in pharmacies is 180 rubles.

Release form and composition

Sustained-release tablets, coated white or almost white, oval, biconvex, possibly with a notch and engraving. Sold in plastic bottles or carton packs.

  • The active substance is metoprolol succinate.
  • Auxiliary substances - ethylcellulose, giproloza, hypromellose, microcrystalline cellulose, paraffin, macrogol, silicon dioxide, sodium fumarate, titanium dioxide.

Pharmacological effect

Betalok ZOK, which helps with heart problems, is a cardioselective beta1-adrenoreceptor blocker, has antiarrhythmic, antianginal and hypotensive effects.

The active active ingredient Betaloka reduces or eliminates the stimulating effect of catecholamines during stress and physical exertion, reduces myocardial contractility and cardiac output, reduces high blood pressure and heart rate. In addition, metoprolol reduces the need for myocardium in oxygen and prolongs the period of diastole. The drug can slightly increase the level of TG, and also slightly reduce the HDL fraction and the levels of free fatty acids in the blood plasma. Betalok ZOK is completely absorbed. Absorption does not depend on meal times.

Tablets are characterized by a sustained release of the active substance, therefore, the drug concentration in the blood plasma remains unchanged, which provides a stable clinical effect for a day or more. The drug is characterized by better tolerance than its counterparts, the risk of developing undesirable side effects is markedly reduced.

Indications for use

Before you take Betalok Zok, you need to carefully study the indications for the use of tablets. Among the main diseases for which you need a medication, the following deviations:

  • angina pectoris (a type of coronary heart disease);
  • hypertension (regular increase in blood pressure);
  • rehabilitation after acute myocardial infarction (to reduce the risk of recurrence of the attack, death);
  • migraine prophylaxis;
  • functional failures in the heart, which are accompanied by tachycardia (an increase in pulse rate, palpitations with pain);
  • the need for additional treatment in chronic heart failure with pronounced symptoms, pathology of the systolic function of the left heart ventricle;
  • supraventricular tachycardia, reducing the frequency of cardiac ventricular contractions in extrasystoles and atrial fibrillation.

Contraindications

Tablets are not prescribed for the treatment of patients with such disorders and pathologies:

  • Hypotension;
  • Severe peripheral circulatory disorders;
  • Suspected acute myocardial infarction;
  • Chronic heart failure in the stage of decompensation;
  • AV blockade 2 and 3 degrees;
  • Cardiogenic shock;
  • Age up to 18 years;
  • Individual intolerance to the components of the drug;
  • Hypersensitivity to drugs from the group of beta-blockers.

The drug with particular caution should be taken in patients with impaired liver and kidney function, diabetes, metabolic acidosis, bronchial asthma.

Use during pregnancy and lactation

The drug is not recommended to appoint for the treatment of women who grow up a child. Also, it should not be taken during lactation. But there are exceptions - cases where the intended benefits to the mother will significantly exceed the risk that exists for the normal development of the fetus or child.

After all, the active substances of antihypertensive drugs often lead to the emergence of various side effects in children.

Instructions for use

The instructions for use indicate that Betalok ZOK is intended for daily intake of 1 time / day, it is recommended to take the drug in the morning.

Angina Pectoris:

  • 100-200 mg Betalok ZOK 1 time / day. If necessary, another antianginal drug may be added to therapy.

Arterial hypertension:

  • 50-100 mg 1 time / day. If necessary, the dose can be increased to 100 mg 1 time / day or use Betalok ZOK in combination with other antihypertensive agents, preferably a diuretic and a calcium channel blocker, a derivative of dihydropyridine.

Stable symptomatic chronic heart failure with impaired left ventricular systolic function:

  • Patients should be in a stage of stable chronic heart failure without episodes of exacerbation during the last 6 weeks and without changes in the main therapy during the last 2 weeks. Therapy of heart failure with beta-blockers can sometimes lead to a temporary worsening of the symptomatic picture. In some cases, it is possible to continue therapy or reduce the dose, in some cases it may be necessary to discontinue the drug.

Stable chronic heart failure, III-IV functional class:

  • The recommended initial dose in the first 2 weeks is 12.5 mg of Betalok ZOK (half a tablet of 25 mg) 1 time / day. The dose is selected individually. During the period of increasing the dose, the patient should be under observation, since in some patients, the symptoms of heart failure may worsen. After 1-2 weeks, the dose may be increased to 25 mg of Betalok ZOK 1 time / day. Then after 2 weeks, the dose may be increased to 50 mg 1 time / day. Patients who tolerate the drug, you can double the dose every 2 weeks until reaching the maximum dose of 200 mg of Betalok ZOK 1 time / day.
  • In the case of arterial hypotension and / or bradycardia, a reduction in concomitant therapy or a reduction in the dose of Betaloc ORA may be needed. Hypotension at the beginning of therapy does not necessarily indicate that this dose of Betalok ZOK will not be tolerated with further long-term treatment. However, the dose should not be increased until the condition stabilizes. Control of renal function may be required.

Stable chronic heart failure, functional class II:

  • The recommended initial dose of Betalok ZOK the first 2 weeks of 25 mg 1 time / day. After 2 weeks of therapy, the dose can be increased to 50 mg 1 time / day, and then it can double every 2 weeks. Maintenance dose for long-term treatment 200 mg Betalok ZOK 1 time / day.

Heart rhythm disorders:

  • 100-200 mg Betalok ZOK 1 time / day.

Functional disorders of cardiac activity, accompanied by tachycardia:

  • 100 mg Betalok ZOK 1 time / day, if necessary, the dose can be increased to 200 mg / day.

Maintenance treatment after myocardial infarction:

  • 200 mg Betalok ZOK 1 time / day.

Prevention of migraine attacks:

  • 100-200 mg Betalok ZOK 1 time / day.

When selecting the dose, it is necessary to avoid the development of bradycardia. The pill should be swallowed with a liquid. Tablets (or tablets divided in half) should not be chewed or crushed. Food intake does not affect the bioavailability of the drug.

Side effects

Such adverse reactions are possible:

  1. Exchange processes: weight gain;
  2. Musculoskeletal system: joint pain;
  3. Hematopoietic system: a decrease in the number of platelets;
  4. Reproductive system: disorders of sexual desire, impotence;
  5. Respiratory system: bronchial spasm, dyspnea on exertion, runny nose;
  6. Digestive system: abdominal pain, disorders of the digestive processes, dryness of the oral mucous membranes, inflammation of the liver, vomiting, disruption of the normal activity of the liver;
  7. Allergic skin lesions: rash, hair loss, exacerbation of the course of psoriasis, increased sweating, increased sensitivity to sunlight;
  8. Since the cardiovascular system: often - cold extremities, bradycardia, palpitations, orthostatic hypotension (including in very rare cases accompanied by fainting); infrequently - AV-blockade of I degree, transient increase in symptoms of heart failure, edema, pain in the heart area, cardiogenic shock in acute myocardial infarction; rarely, arrhythmias, other conduction disorders; very rarely - gangrene (against the background of a severe violation of the peripheral circulation);
  9. Central and peripheral nervous system: dizziness, involuntary muscle contractions, nausea, depressive states, sleep disorders, drowsiness, increased nervous excitability, impaired memory and reproduction of information, depressed mood, increased fatigue, headaches, convulsions, impaired concentration, increased anxiety , memory loss, the appearance of hallucinations.

As a rule, when used correctly, the medicine is well tolerated by patients to whom it is prescribed. Side effects are minor or easily reversible.

Overdose

More than 7.5 g of betaloc intravenously can cause death. From 1.4 to 7.5 g lead to severe / moderate intoxication. Symptoms of drug overdose are seen an hour or two after taking it. The most common are:

  • Trembling limbs;
  • Cramps / cramps;
  • Nausea, vomiting;
  • Slow heartbeat;
  • Loss of consciousness;
  • Decreased blood pressure;
  • Cardiogenic shock;
  • Satiated body potassium;
  • Heart failure;
  • Feeling short of breath;
  • Difficult breathing (and other problems with the lungs) and some. others

First aid - the appointment of activated carbon, intravenous (IV) administration of atropine at a dose of 0.25-0.5 mg for adults, for children - at the rate of 0.01-0.02 mg per 1 kg of child's weight (iz- for the risk of stimulating the vagus nerve, atropine administration is prescribed before gastric lavage!) Symptomatic therapy is carried out. If necessary, carry out gastric lavage, electrocardiography, measures to maintain the airway and adequate ventilation of the lungs.

Special instructions

  1. Intravenous administration of slow calcium channel blockers is contraindicated in patients taking beta-blockers.
  2. The use of the drug in patients with asthma or COPD should be carried out in the minimum effective dose and be accompanied by the appointment of beta2-adrenomimetika. If necessary, dose beta2-adrenomimetika increase.
  3. If during treatment occurred bradycardia, the dose should be reduced or gradually discontinued the drug.
  4. The therapy may increase the symptoms of peripheral arterial circulation disorders.
  5. Beta1-adrenergic blockers have less effect on the disturbance of carbohydrate metabolism or masking of the symptoms of hypoglycemia as compared with non-selective beta-blockers.
  6. Taking the drug can cause fatigue and dizziness, which must be taken into account when driving motor vehicles, as well as taking up potentially dangerous work requiring increased attention and speed of psychomotor reactions.
  7. Abrupt cancellation of metoprolol is dangerous, so it should be avoided. Discontinuation of the drug should be gradual - within two weeks with a twofold decrease in dose.

Drug interactions

Non-steroidal anti-inflammatory drugs, in particular, diclofenac, weaken the antihypertensive effect of metoprolol and other beta-blockers. With the combination of the drug Betalok with diltiazem, cases of severe bradycardia were observed. Tell your doctor about all other medications you are taking and discuss possible interactions with them.

Reviews

We picked up some feedback from people about the preparation of Betalok ZOK:

  1. Valentine. I accept betalok more than 3 years. The pressure rarely rises. Pulse to 60. In addition, I have 2 diabetes mellitus keeps 7. I consider a good drug (100 mg 1 time per day).
  2. Oleg. The employee suffers from hypertension and arrhythmia, and no doctor can figure out the type of arrhythmia (it is accompanied by increased pressure and increased heart rate), and often began to complain of headaches. A colleague tried many different types of pills and drops from arrhythmia, but nothing gave a significant effect. I advised her about the pills of “Beetloc ZOK”, which my grandmother uses, she has the same symptoms of the disease. The pills act almost immediately, the pulse returns to normal and the pressure drops. Very effective drug. In any case, before use, you should consult with the doctor so that he chooses the desired dosage.

Good drug reviews by doctors also deserve the fact that, according to the results of many studies, its main component, metaprolol, has the property of prolonging life. Despite the fact that cardiologists, this drug is on a fairly good account, there is a certain category of people who, while taking these pills, doctors are advised to take additional safety measures.

Among such recommendations are:

  1. Regularly checking blood glucose levels in people with diabetes. It is necessary to take into account the fact that, as a beta-blocker, "Betalok ZOK can mask tachycardia, which occurs due to hypoglycemia. At the beginning of taking the pills, each patient is recommended by cardiologists to measure blood pressure daily and monitor the pulse. In cases when receiving "Betalok ZOK", heart rate is less than 50 beats per minute, cardiologists strongly recommend to seek medical advice.
  2. Older patients who take this medicine are recommended by doctors to monitor their kidney function at least once every 6 months.

Analogs

Analogs of Betaloka ZOK are: Azoprol Retard, Corvitol, Vazokardin, Metoprolol, Metoprolol Tartrate, Metoprolol Zentiva, Metocor, Egilok Retard.

Before using analogues consult your doctor.

Storage conditions and shelf life

The drug should be kept in a dark and cool place out of the reach of children.

The drug can be stored for three years from the date of manufacture. After the expiration date, taking the medicine is strictly prohibited.

Watch the video: Metoprolol Side Effects (December 2019).

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